Nature between science and wisdom
ERBAGIL RESEARCH
Erbagil® Research is the driving force behind the company's scientific innovation, dedicated to the development of cutting-edge solutions in the health, wellness, and beauty sectors.
Through years of advanced studies and experimentation, Erbagil® Ricerca has patented unique solutions such as Ozoile® , Stamiuvex® and SEM , which represent a true revolution in cell regeneration, anti-aging treatments and bioactive extraction respectively.
Erbagil® and University Collaborations: A Bridge between Innovation and Education
Erbagil® has established strong partnerships with several Italian and international universities, fostering mutual growth between industry and academia. These collaborations allow Erbagil® access to the latest scientific research, experiments, and technological innovations, which enrich its development projects.
At the same time, these partnerships promote the training of young talents and researchers, offering them internships and placements in the biotechnology and medical fields. The agreements allow Erbagil® to share know-how and resources with universities, fostering the development of new patents and advanced scientific solutions. Thanks to these synergies, the company contributes to the advancement of the health and wellness sector, remaining at the forefront of innovation and sustainability.
Erbagil® Exclusive Patents Research
Grazie alla nostra continua ricerca, abbiamo sviluppato brevetti come Ozoile®, che unisce l’ozono all’olio extravergine di oliva biologico +OIL, formando Ozonidi Stabili, isolati e completamente caratterizzati, dalle azioni curative rigeneranti antinfiammatorie,antimicrobiche e antiproliferative.
Il brevetto Stamiuvex®, invece, sfrutta le proprietà delle cellule staminali delle bacche d’uva, per combattere l’invecchiamento e promuovere la rigenerazione cellulare per una riprogrammazione anti age. S.E.M, Stistema Estrattivo Multifasico, è una tecnologia innovativa che permette l’estrazione ad alta resa di composti biologicamente attivi (BACs) da matrici vegetali, preservandone la struttura chimica senza alterazioni. "Il brevetto MICROCELLETTE RICARICABILI è una tecnologia in grado di rivoluzionare il settore delle medicazioni elastiche, permettendo la diffusione e la ricarica di Ozoile nel bendaggio senza doverlo rimuovere, offrendo un'azione terapeutica personalizzata con diverse formulazioni per uso topico
Erbagil® and Its Space Revolution
Erbagil® has achieved an extraordinary milestone by participating in the prestigious NASA Cygnus NG-20 mission, contributing its innovative approach to microgravity research. The mission, launched from the Kennedy Space Center via the Falcon 9 rocket, saw Erbagil® collaborate in the creation of a mini laboratory transported into space. The laboratory contains Ozoile, designed to analyze cellular aging processes in microgravity conditions.
This unique experiment represents an important step not only for Erbagil® but for the entire scientific community. The mission's goal is to understand the evolution of cellular processes in the absence of gravity and discover possible applications in the field of health and well-being, especially in relation to age-related pathologies. The presence of Erbagil® in a NASA space mission marks an international recognition for the company, affirming its ability to combine innovative research and sustainability with concrete results.
RESEARCH PROJECTS, AGREEMENTS AND COLLABORATIONS
Erbagil® supports scientific research through numerous agreements and collaborations with Italian and international universities. These projects aim to study in depth the properties of Ozoile®, its derivatives, and other innovative ingredients, promoting their applications in the medical, nutraceutical, and cosmetic fields.
EXISTING AGREEMENTS
1. NASA – Prof. Geppino Falco (Federico II University of Naples)
- Agreement for Microgravity Studies at NASA.
- Objective: To evaluate cellular aging through organoid models and study inflammatory processes.
- First launch already completed (osteoporotic processes on mesenchymal cells), second launch planned to evaluate the interaction with the intestinal microbiome using Ozoile®, Ozoile® + Lycopene and different combinations of ozonides.
- Results: good tolerability, confirmed anti-inflammatory effect and promotion of cell differentiation in microgravity conditions and on the ground.
- The minilab for the second launch is an exclusive design by Prof. Falco.
2. Anti-inflammatory properties – Prof. Falco (Federico II University of Naples)
- Studies on gastrointestinal organoids to evaluate the anti-inflammatory effect of Ozoile® and the “patch” function in combination with Lycopene, for potential applications in celiac subjects.
3. Clays – Prof. Rosaria Riela (University of Catania)
- Funded collaboration.
- Objective: Delivery of Ozoile® and Ozoile® + Lycopene in natural clays to create thixotropic gels, improve the potency of Ozogea® and avoid solvents in cellular delivery.
4. Tumor Cells – Professor Monica Notarbartolo (University of Palermo)
- Study of the antiproliferative activity of Ozoile® on tumor and healthy cell lines (breast, leukemic).
- Tests on conveyance with solvents and natural clays.
- Participation in the PNRR Agritech project.
- Results indicate increasing antiproliferative activity with increasing concentration of stable ozonides.
5. Antiproliferative Activity – Professor Laura Businaro (Sapienza University of Rome)
- Study on the antiproliferative/antitumor properties of Ozoile®, Ozoile® + Lycopene and +Oil.
- Models: Human neuroblastoma (SH-SY5Y, SK-N-SH, NB41) and glioblastoma (U87, U251, U373) neural tumor lines.
- In-depth analysis of the apoptotic mechanism and statistical support.
6. Laboratory Animals – Professor Diana Amantea (University of Calabria)
- Active collaboration through a three-year Industrial Doctorate starting in November 2024.
- Presence of the PhD student in the company for one semester.
- In vivo studies in mice to evaluate prevention and treatment of neurodegeneration.
- Results: no direct neuroprotection but confirmed antioxidant activity on plasma and safety (absence of toxicity).
- The project includes a research stay in England.
7. Genotoxicity and Cytotoxicity – Professors Stornaiuolo and Novellino (Inventia Biotech)
- Chemical and food safety/toxicity studies of Ozoile®.
- Objective: prepare dossiers for registration as a Novel Food.
- Results: absence of genotoxicity and cytotoxicity.
- Detailed chemical-physical characterization (acidity, peroxide value, deltaK, iodine value, acid profile, FTIR).
- Feasibility study on the potential for regulating the intestinal microbiome, with promising preliminary results (pathogen reduction and revitalization of beneficial flora).
8. Extraction of active ingredients – Prof. Daniele Naviglio (Federico II University of Naples)
- Extraction trials of plant bioactives with Ozoile® Food using the patented Naviglio® Extractor.
- Excellent results on tomato pigments and prototype recipes (e.g. STREGONCINO).
- Spectrophotometric analyses show controlled oxidability of lycopene.
9. Bioavailability and nutritional value – Prof. Günter Bonn and Thomas Jakschitz (University of Innsbruck/ADSI)
- Study of the energy content of Ozoile®.
- In vitro evaluation of the ability to cross biological membranes to analyze bioaccessibility and bioavailability.
- Aimed at the candidacy of Ozoile® Food as a Novel Food to the European Commission.
10. Stability of Ozoile® Food + Lycopene – Professors Pietro Campiglia and Giacomo Pepe (University of Salerno)
- Analysis of lycopene degradation in the presence of Ozoile® and formation of oxidized species.
- Qualitative and quantitative evaluation of stable ozonides and degraded lycopene.
- Study of the transformation kinetics of oxidized species.
- Analysis of acid profiles and standards of stable ozonides in mixtures.
AGREEMENTS IN PROGRESS
11. Antihyperglycemic activity – Prof. Ambrosino (Federico II University of Naples)
- Study on animal models (mice) to evaluate the antidiabetic properties of Ozoile®, Ozoile® + Lycopene and +Oil®.
- Preparatory to future clinical trials on patients.
12. Antidiabetic activity – Prof. Marfella (Vanvitelli University of Caserta)
- Clinical study on patients with metabolic syndrome.
- Objectives: to evaluate the antihyperglycemic, antihypertensive, antihypercholesterolemic and antihypertriglyceridemic effects of Ozoile® and the new supplement OZOMETRIX®.
13. Iron citrate supplement – Prof. Daniele Naviglio (Federico II University of Naples)
- Study to create a food supplement based on iron(II) citrate starting from apple juice rich in organic acids.
- Use of the SEM patent for extraction and combination with iron filings, obtaining a highly bioavailable salt useful for correcting iron deficiencies.
RESEARCH PROJECTS, AGREEMENTS AND COLLABORATIONS
Erbagil® supports scientific research through numerous agreements and collaborations with Italian and international universities. These projects aim to study in depth the properties of Ozoile®, its derivatives, and other innovative ingredients, promoting their applications in the medical, nutraceutical, and cosmetic fields.
EXISTING AGREEMENTS
1. NASA – Prof. Geppino Falco (Federico II University of Naples)
- Agreement for Microgravity Studies at NASA.
- Objective: To evaluate cellular aging through organoid models and study inflammatory processes.
- First launch already completed (osteoporotic processes on mesenchymal cells), second launch planned to evaluate the interaction with the intestinal microbiome using Ozoile®, Ozoile® + Lycopene and different combinations of ozonides.
- Results: good tolerability, confirmed anti-inflammatory effect and promotion of cell differentiation in microgravity conditions and on the ground.
- The minilab for the second launch is an exclusive design by Prof. Falco.
2. Anti-inflammatory properties – Prof. Falco (Federico II University of Naples)
- Studies on gastrointestinal organoids to evaluate the anti-inflammatory effect of Ozoile® and the “patch” function in combination with Lycopene, for potential applications in celiac subjects.
3. Clays – Prof. Rosaria Riela (University of Catania)
- Funded collaboration.
- Objective: Delivery of Ozoile® and Ozoile® + Lycopene in natural clays to create thixotropic gels, improve the potency of Ozogea® and avoid solvents in cellular delivery.
4. Tumor Cells – Professor Monica Notarbartolo (University of Palermo)
- Study of the antiproliferative activity of Ozoile® on tumor and healthy cell lines (breast, leukemic).
- Tests on conveyance with solvents and natural clays.
- Participation in the PNRR Agritech project.
- Results indicate increasing antiproliferative activity with increasing concentration of stable ozonides.
5. Antiproliferative Activity – Professor Laura Businaro (Sapienza University of Rome)
- Study on the antiproliferative/antitumor properties of Ozoile®, Ozoile® + Lycopene and +Oil.
- Models: Human neuroblastoma (SH-SY5Y, SK-N-SH, NB41) and glioblastoma (U87, U251, U373) neural tumor lines.
- In-depth analysis of the apoptotic mechanism and statistical support.
6. Laboratory Animals – Professor Diana Amantea (University of Calabria)
- Active collaboration through a three-year Industrial Doctorate starting in November 2024.
- Presence of the PhD student in the company for one semester.
- In vivo studies in mice to evaluate prevention and treatment of neurodegeneration.
- Results: no direct neuroprotection but confirmed antioxidant activity on plasma and safety (absence of toxicity).
- The project includes a research stay in England.
7. Genotoxicity and Cytotoxicity – Professors Stornaiuolo and Novellino (Inventia Biotech)
- Chemical and food safety/toxicity studies of Ozoile®.
- Objective: prepare dossiers for registration as a Novel Food.
- Results: absence of genotoxicity and cytotoxicity.
- Detailed chemical-physical characterization (acidity, peroxide value, deltaK, iodine value, acid profile, FTIR).
- Feasibility study on the potential for regulating the intestinal microbiome, with promising preliminary results (pathogen reduction and revitalization of beneficial flora).
8. Extraction of active ingredients – Prof. Daniele Naviglio (Federico II University of Naples)
- Extraction trials of plant bioactives with Ozoile® Food using the patented Naviglio® Extractor.
- Excellent results on tomato pigments and prototype recipes (e.g. STREGONCINO).
- Spectrophotometric analyses show controlled oxidability of lycopene.
9. Bioavailability and nutritional value – Prof. Günter Bonn and Thomas Jakschitz (University of Innsbruck/ADSI)
- Study of the energy content of Ozoile®.
- In vitro evaluation of the ability to cross biological membranes to analyze bioaccessibility and bioavailability.
- Aimed at the candidacy of Ozoile® Food as a Novel Food to the European Commission.
10. Stability of Ozoile® Food + Lycopene – Professors Pietro Campiglia and Giacomo Pepe (University of Salerno)
- Analysis of lycopene degradation in the presence of Ozoile® and formation of oxidized species.
- Qualitative and quantitative evaluation of stable ozonides and degraded lycopene.
- Study of the transformation kinetics of oxidized species.
- Analysis of acid profiles and standards of stable ozonides in mixtures.
AGREEMENTS IN PROGRESS
11. Antihyperglycemic activity – Prof. Ambrosino (Federico II University of Naples)
- Study on animal models (mice) to evaluate the antidiabetic properties of Ozoile®, Ozoile® + Lycopene and +Oil®.
- Preparatory to future clinical trials on patients.
12. Antidiabetic activity – Prof. Marfella (Vanvitelli University of Caserta)
- Clinical study on patients with metabolic syndrome.
- Objectives: to evaluate the antihyperglycemic, antihypertensive, antihypercholesterolemic and antihypertriglyceridemic effects of Ozoile® and the new supplement OZOMETRIX®.
13. Iron citrate supplement – Prof. Daniele Naviglio (Federico II University of Naples)
- Study to create a food supplement based on iron(II) citrate starting from apple juice rich in organic acids.
- Use of the SEM patent for extraction and combination with iron filings, obtaining a highly bioavailable salt useful for correcting iron deficiencies.
Sustainability and Responsible Innovation
In Erbagil® Ricerca, l’attenzione verso l’ambiente è una priorità. Oltre a sviluppare soluzioni innovative per la salute, ci impegniamo a ridurre l’impatto ambientale utilizzando materie prime biologiche e tecnologie sostenibili.
Ogni nostro prodotto è il risultato di un processo che rispetta la biodiversità e promuove un’agricoltura ecocompatibile, in linea con i principi di responsabilità ambientale. La nostra ricerca scientifica guarda al futuro, creando soluzioni efficaci per il benessere delle persone e del pianeta.
