Nature between science and wisdom

ERBAGIL® RESEARCH – ONE OF THE THREE ARTERIES OF THE HEART ERBAGIL®

Erbagil® Research is the scientific soul of the company and one of the three arteries that feed the heart of the Erbagil® Supply Chain, together with Erbagil® Tenuta and Erbagil® Produzione .

In this virtuous flow, Research represents the bridge between nature and technology: it processes the raw material coming from the Estate and transforms it into applied knowledge, ready to become industrial innovation through Production .

This is where the exclusive Ozoile® , Stamiuvex® and SEM patents come to life, the result of years of advanced studies and experiments that have redefined the boundaries of cellular regeneration, anti-aging treatments and bioactive extraction.

Erbagil® Research is not just a research center, but a driving force that drives the entire supply chain: from scientific intuition to the concreteness of the product.

Three arteries, one heart: Erbagil®.
Erbagil

Erbagil® and University Collaborations: A Bridge between Innovation and Education

Erbagil® has established strong partnerships with several Italian and international universities, fostering mutual growth between industry and academia. These collaborations allow Erbagil® access to the latest scientific research, experiments, and technological innovations, which enrich its development projects.

At the same time, these partnerships promote the training of young talents and researchers, offering them internships and placements in the biotechnology and medical fields. The agreements allow Erbagil® to share know-how and resources with universities, fostering the development of new patents and advanced scientific solutions. Thanks to these synergies, the company contributes to the advancement of the health and wellness sector, remaining at the forefront of innovation and sustainability.

Erbagil® Exclusive Patents Research

Grazie alla nostra continua ricerca, abbiamo sviluppato brevetti come Ozoile®, che unisce l’ozono all’olio extravergine di oliva biologico +OIL, formando Ozonidi Stabili, isolati e completamente caratterizzati, dalle azioni curative rigeneranti antinfiammatorie,antimicrobiche e antiproliferative.
Il brevetto Stamiuvex®, invece, sfrutta le proprietà delle cellule staminali delle bacche d’uva, per combattere l’invecchiamento e promuovere la rigenerazione cellulare per una riprogrammazione anti age. S.E.M, Stistema Estrattivo Multifasico, è una tecnologia innovativa che permette l’estrazione ad alta resa di composti biologicamente attivi (BACs) da matrici vegetali, preservandone la struttura chimica senza alterazioni. "Il brevetto MICROCELLETTE RICARICABILI è una tecnologia in grado di rivoluzionare il settore delle medicazioni elastiche, permettendo la diffusione e la ricarica di Ozoile nel bendaggio senza doverlo rimuovere, offrendo un'azione terapeutica personalizzata con diverse formulazioni per uso topico

Erbagil

Erbagil® and Its Space Revolution

Erbagil® has achieved a scientific milestone of international significance by participating in the prestigious NG-20 Cygnus mission, which culminated with the launch of the Falcon 9 rocket from the Kennedy Space Center . As part of the mission, the MiniLab 1.0 , intended for biological research, was transported into orbit aboard the Falcon 9 with the aim of testing molecules capable of mitigating cellular aging processes in microgravity conditions.

The entire mission was made possible thanks to the strong collaboration between Erbagil® and the Department of Biology at Federico II University, within a scientific agreement that combined academic expertise and industrial innovation capabilities. The research group led by Professor Geppino Falco, full professor at the aforementioned Department, conducted a series of studies on Ozoile® in its laboratories to evaluate its biological activities, including its effect on the viability and differentiation of mesenchymal stem cells in the molecular processes associated with osteoporosis.

Based on the results obtained, Ozoile® was deemed an important and innovative product worthy of inclusion in the READI SP project, conceived by Prof. Falco and supported by Erbagil® Ricerca, resulting in the launch of the MiniLab into space, reaching the International Space Station.

This experience represents not only international recognition for Erbagil®, but also a concrete example of how the synergy between research and business can generate cutting-edge, sustainable solutions projected towards the future of regenerative medicine – even beyond the confines of the Earth.

ERBAGIL: HEALTH AGREEMENTS. BETWEEN NATURE AND SCIENCE.

RESEARCH PROJECTS, AGREEMENTS AND COLLABORATIONS

Erbagil® supports scientific research through numerous agreements and collaborations with Italian and international universities. These projects aim to study in depth the properties of Ozoile®, its derivatives, and other innovative ingredients, promoting their applications in the medical, nutraceutical, and cosmetic fields.

EXISTING AGREEMENTS

1. NASA – Prof. Geppino Falco (Federico II University of Naples)

  • Agreement for Microgravity Studies at NASA.
  • Objective: To evaluate cellular aging through organoid models and study inflammatory processes.
  • First launch already completed (osteoporotic processes on mesenchymal cells), second launch planned to evaluate the interaction with the intestinal microbiome using Ozoile®, Ozoile® + Lycopene and different combinations of ozonides.
  • Results: good tolerability, confirmed anti-inflammatory effect and promotion of cell differentiation in microgravity conditions and on the ground.
  • The minilab for the second launch is an exclusive design by Prof. Falco.

2. Anti-inflammatory properties – Prof. Falco (Federico II University of Naples)

  • Studies on gastrointestinal organoids to evaluate the anti-inflammatory effect of Ozoile® and the “patch” function in combination with Lycopene, for potential applications in celiac subjects.

3. Clays – Prof. Rosaria Riela (University of Catania)

  • Funded collaboration.
  • Objective: Delivery of Ozoile® and Ozoile® + Lycopene in natural clays to create thixotropic gels, improve the potency of Ozogea® and avoid solvents in cellular delivery.

4. Tumor Cells – Professor Monica Notarbartolo (University of Palermo)

  • Study of the antiproliferative activity of Ozoile® on tumor and healthy cell lines (breast, leukemic).
  • Tests on conveyance with solvents and natural clays.
  • Participation in the PNRR Agritech project.
  • Results indicate increasing antiproliferative activity with increasing concentration of stable ozonides.

5. Antiproliferative Activity – Professor Laura Businaro (Sapienza University of Rome)

  • Study on the antiproliferative/antitumor properties of Ozoile®, Ozoile® + Lycopene and +Oil.
  • Models: Human neuroblastoma (SH-SY5Y, SK-N-SH, NB41) and glioblastoma (U87, U251, U373) neural tumor lines.
  • In-depth analysis of the apoptotic mechanism and statistical support.

6. Laboratory Animals – Professor Diana Amantea (University of Calabria)

  • Active collaboration through a three-year Industrial Doctorate starting in November 2024.
  • Presence of the PhD student in the company for one semester.
  • In vivo studies in mice to evaluate prevention and treatment of neurodegeneration.
  • Results: no direct neuroprotection but confirmed antioxidant activity on plasma and safety (absence of toxicity).
  • The project includes a research stay in England.

7. Genotoxicity and Cytotoxicity – Professors Stornaiuolo and Novellino (Inventia Biotech)

  • Chemical and food safety/toxicity studies of Ozoile®.
  • Objective: prepare dossiers for registration as a Novel Food.
  • Results: absence of genotoxicity and cytotoxicity.
  • Detailed chemical-physical characterization (acidity, peroxide value, deltaK, iodine value, acid profile, FTIR).
  • Feasibility study on the potential for regulating the intestinal microbiome, with promising preliminary results (pathogen reduction and revitalization of beneficial flora).

8. Extraction of active ingredients – Prof. Daniele Naviglio (Federico II University of Naples)

  • Extraction trials of plant bioactives with Ozoile® Food using the patented Naviglio® Extractor.
  • Excellent results on tomato pigments and prototype recipes (e.g. STREGONCINO).
  • Spectrophotometric analyses show controlled oxidability of lycopene.

9. Bioavailability and nutritional value – Prof. Günter Bonn and Thomas Jakschitz (University of Innsbruck/ADSI)

  • Study of the energy content of Ozoile®.
  • In vitro evaluation of the ability to cross biological membranes to analyze bioaccessibility and bioavailability.
  • Aimed at the candidacy of Ozoile® Food as a Novel Food to the European Commission.

10. Stability of Ozoile® Food + Lycopene – Professors Pietro Campiglia and Giacomo Pepe (University of Salerno)

  • Analysis of lycopene degradation in the presence of Ozoile® and formation of oxidized species.
  • Qualitative and quantitative evaluation of stable ozonides and degraded lycopene.
  • Study of the transformation kinetics of oxidized species.
  • Analysis of acid profiles and standards of stable ozonides in mixtures.

AGREEMENTS IN PROGRESS

11. Antihyperglycemic activity – Prof. Ambrosino (Federico II University of Naples)

  • Study on animal models (mice) to evaluate the antidiabetic properties of Ozoile®, Ozoile® + Lycopene and +Oil®.
  • Preparatory to future clinical trials on patients.

12. Antidiabetic activity – Prof. Marfella (Vanvitelli University of Caserta)

  • Clinical study on patients with metabolic syndrome.
  • Objectives: to evaluate the antihyperglycemic, antihypertensive, antihypercholesterolemic and antihypertriglyceridemic effects of Ozoile® and the new supplement OZOMETRIX®.

13. Iron citrate supplement – Prof. Daniele Naviglio (Federico II University of Naples)

  • Study to create a food supplement based on iron(II) citrate starting from apple juice rich in organic acids.
  • Use of the SEM patent for extraction and combination with iron filings, obtaining a highly bioavailable salt useful for correcting iron deficiencies.

RESEARCH PROJECTS, AGREEMENTS AND COLLABORATIONS

Erbagil® supports scientific research through numerous agreements and collaborations with Italian and international universities. These projects aim to study in depth the properties of Ozoile®, its derivatives, and other innovative ingredients, promoting their applications in the medical, nutraceutical, and cosmetic fields.

EXISTING AGREEMENTS

1. NASA – Prof. Geppino Falco (Federico II University of Naples)

  • Agreement for Microgravity Studies at NASA.
  • Objective: To evaluate cellular aging through organoid models and study inflammatory processes.
  • First launch already completed (osteoporotic processes on mesenchymal cells), second launch planned to evaluate the interaction with the intestinal microbiome using Ozoile®, Ozoile® + Lycopene and different combinations of ozonides.
  • Results: good tolerability, confirmed anti-inflammatory effect and promotion of cell differentiation in microgravity conditions and on the ground.
  • The minilab for the second launch is an exclusive design by Prof. Falco.

2. Anti-inflammatory properties – Prof. Falco (Federico II University of Naples)

  • Studies on gastrointestinal organoids to evaluate the anti-inflammatory effect of Ozoile® and the “patch” function in combination with Lycopene, for potential applications in celiac subjects.

3. Clays – Prof. Rosaria Riela (University of Catania)

  • Funded collaboration.
  • Objective: Delivery of Ozoile® and Ozoile® + Lycopene in natural clays to create thixotropic gels, improve the potency of Ozogea® and avoid solvents in cellular delivery.

4. Tumor Cells – Professor Monica Notarbartolo (University of Palermo)

  • Study of the antiproliferative activity of Ozoile® on tumor and healthy cell lines (breast, leukemic).
  • Tests on conveyance with solvents and natural clays.
  • Participation in the PNRR Agritech project.
  • Results indicate increasing antiproliferative activity with increasing concentration of stable ozonides.

5. Antiproliferative Activity – Professor Laura Businaro (Sapienza University of Rome)

  • Study on the antiproliferative/antitumor properties of Ozoile®, Ozoile® + Lycopene and +Oil.
  • Models: Human neuroblastoma (SH-SY5Y, SK-N-SH, NB41) and glioblastoma (U87, U251, U373) neural tumor lines.
  • In-depth analysis of the apoptotic mechanism and statistical support.

6. Laboratory Animals – Professor Diana Amantea (University of Calabria)

  • Active collaboration through a three-year Industrial Doctorate starting in November 2024.
  • Presence of the PhD student in the company for one semester.
  • In vivo studies in mice to evaluate prevention and treatment of neurodegeneration.
  • Results: no direct neuroprotection but confirmed antioxidant activity on plasma and safety (absence of toxicity).
  • The project includes a research stay in England.

7. Genotoxicity and Cytotoxicity – Professors Stornaiuolo and Novellino (Inventia Biotech)

  • Chemical and food safety/toxicity studies of Ozoile®.
  • Objective: prepare dossiers for registration as a Novel Food.
  • Results: absence of genotoxicity and cytotoxicity.
  • Detailed chemical-physical characterization (acidity, peroxide value, deltaK, iodine value, acid profile, FTIR).
  • Feasibility study on the potential for regulating the intestinal microbiome, with promising preliminary results (pathogen reduction and revitalization of beneficial flora).

8. Extraction of active ingredients – Prof. Daniele Naviglio (Federico II University of Naples)

  • Extraction trials of plant bioactives with Ozoile® Food using the patented Naviglio® Extractor.
  • Excellent results on tomato pigments and prototype recipes (e.g. STREGONCINO).
  • Spectrophotometric analyses show controlled oxidability of lycopene.

9. Bioavailability and nutritional value – Prof. Günter Bonn and Thomas Jakschitz (University of Innsbruck/ADSI)

  • Study of the energy content of Ozoile®.
  • In vitro evaluation of the ability to cross biological membranes to analyze bioaccessibility and bioavailability.
  • Aimed at the candidacy of Ozoile® Food as a Novel Food to the European Commission.

10. Stability of Ozoile® Food + Lycopene – Professors Pietro Campiglia and Giacomo Pepe (University of Salerno)

  • Analysis of lycopene degradation in the presence of Ozoile® and formation of oxidized species.
  • Qualitative and quantitative evaluation of stable ozonides and degraded lycopene.
  • Study of the transformation kinetics of oxidized species.
  • Analysis of acid profiles and standards of stable ozonides in mixtures.

AGREEMENTS IN PROGRESS

11. Antihyperglycemic activity – Prof. Ambrosino (Federico II University of Naples)

  • Study on animal models (mice) to evaluate the antidiabetic properties of Ozoile®, Ozoile® + Lycopene and +Oil®.
  • Preparatory to future clinical trials on patients.

12. Antidiabetic activity – Prof. Marfella (Vanvitelli University of Caserta)

  • Clinical study on patients with metabolic syndrome.
  • Objectives: to evaluate the antihyperglycemic, antihypertensive, antihypercholesterolemic and antihypertriglyceridemic effects of Ozoile® and the new supplement OZOMETRIX®.

13. Iron citrate supplement – Prof. Daniele Naviglio (Federico II University of Naples)

  • Study to create a food supplement based on iron(II) citrate starting from apple juice rich in organic acids.
  • Use of the SEM patent for extraction and combination with iron filings, obtaining a highly bioavailable salt useful for correcting iron deficiencies.

Sustainability and Responsible Innovation

In Erbagil® Ricerca, l’attenzione verso l’ambiente è una priorità. Oltre a sviluppare soluzioni innovative per la salute, ci impegniamo a ridurre l’impatto ambientale utilizzando materie prime biologiche e tecnologie sostenibili.
Ogni nostro prodotto è il risultato di un processo che rispetta la biodiversità e promuove un’agricoltura ecocompatibile, in linea con i principi di responsabilità ambientale. La nostra ricerca scientifica guarda al futuro, creando soluzioni efficaci per il benessere delle persone e del pianeta.