Erbagil collaborates with universities and research centers to develop knowledge, validate protocols, and spread a scientific culture based on ethics and responsible innovation. A bridge between business and academia for science at the service of life.

A bridge between academic research and biotechnological enterprise

Erbagil® has established strong partnerships with several Italian and international universities, fostering mutual growth between industry and academia. These collaborations allow Erbagil® access to the latest scientific research, experiments, and technological innovations, which enrich its development projects.

At the same time, these partnerships promote the training of young talents and researchers, offering them internships and placements in the biotechnology and medical fields. The agreements allow Erbagil® to share know-how and resources with universities, fostering the development of new patents and advanced scientific solutions. Thanks to these synergies, the company contributes to the advancement of the health and wellness sector, remaining at the forefront of innovation and sustainability.

Ozoile® at the center of academic research

University collaborations are a key element of Erbagil's research and development. Thanks to ongoing dialogue with universities, medicine, pharmacy, and biotechnology departments, Ozoile®—Erbagil's patented active ingredient—is the subject of numerous scientific studies aimed at validating its mechanisms of action and therapeutic applications.

Through shared protocols, publications, and experimental projects, the company consolidates an innovation model based on academic verification and scientific transparency , transforming collaboration with universities into a permanent laboratory of knowledge.

Each partnership demonstrates Erbagil's commitment to promoting evidence-based, ethical, and rigorous science, with a clear goal: developing safe, effective, and truly beneficial biological solutions for people's health.

PROJECTS, AGREEMENTS AND RESEARCH COLLABORATIONS

Erbagil® supports scientific research through numerous agreements and collaborations with Italian and international universities. These projects aim to study in depth the properties of Ozoile®, its derivatives, and other innovative ingredients, promoting their applications in the medical, nutraceutical, and cosmetic fields.

EXISTING AGREEMENTS

1. NASA – Prof. Geppino Falco (Federico II University of Naples)

  • Agreement for Microgravity Studies at NASA.
  • Objective: To evaluate cellular aging through organoid models and study inflammatory processes.
  • First launch already completed (osteoporotic processes on mesenchymal cells), second launch planned to evaluate the interaction with the intestinal microbiome using Ozoile®, Ozoile® + Lycopene and different combinations of ozonides.
  • Results: good tolerability, confirmed anti-inflammatory effect and promotion of cell differentiation in microgravity conditions and on the ground.
  • The minilab for the second launch is an exclusive design by Prof. Falco.

2. Anti-inflammatory properties – Prof. Falco (Federico II University of Naples)

  • Studies on gastrointestinal organoids to evaluate the anti-inflammatory effect of Ozoile® and the “patch” function in combination with Lycopene, for potential applications in celiac subjects.

3. Clays – Prof. Rosaria Riela (University of Catania)

  • Funded collaboration.
  • Objective: Delivery of Ozoile® and Ozoile® + Lycopene in natural clays to create thixotropic gels, improve the potency of Ozogea® and avoid solvents in cellular delivery.

4. Tumor Cells – Professor Monica Notarbartolo (University of Palermo)

  • Study of the antiproliferative activity of Ozoile® on tumor and healthy cell lines (breast, leukemic).
  • Tests on conveyance with solvents and natural clays.
  • Participation in the PNRR Agritech project.
  • Results indicate increasing antiproliferative activity with increasing concentration of stable ozonides.

5. Antiproliferative Activity – Professor Laura Businaro (Sapienza University of Rome)

  • Study on the antiproliferative/antitumor properties of Ozoile®, Ozoile® + Lycopene and +Oil.
  • Models: Human neuroblastoma (SH-SY5Y, SK-N-SH, NB41) and glioblastoma (U87, U251, U373) neural tumor lines.
  • In-depth analysis of the apoptotic mechanism and statistical support.

6. Laboratory Animals – Professor Diana Amantea (University of Calabria)

  • Active collaboration through a three-year Industrial Doctorate starting in November 2024.
  • Presence of the PhD student in the company for one semester.
  • In vivo studies in mice to evaluate prevention and treatment of neurodegeneration.
  • Results: no direct neuroprotection but confirmed antioxidant activity on plasma and safety (absence of toxicity).
  • The project includes a research stay in England.

7. Genotoxicity and Cytotoxicity – Professors Stornaiuolo and Novellino (Inventia Biotech)

  • Chemical and food safety/toxicity studies of Ozoile®.
  • Objective: prepare dossiers for registration as a Novel Food.
  • Results: absence of genotoxicity and cytotoxicity.
  • Detailed chemical-physical characterization (acidity, peroxide value, deltaK, iodine value, acid profile, FTIR).
  • Feasibility study on the potential for regulating the intestinal microbiome, with promising preliminary results (pathogen reduction and revitalization of beneficial flora).

8. Extraction of active ingredients – Prof. Daniele Naviglio (Federico II University of Naples)

  • Extraction trials of plant bioactives with Ozoile® Food using the patented Naviglio® Extractor.
  • Excellent results on tomato pigments and prototype recipes (e.g. STREGONCINO).
  • Spectrophotometric analyses show controlled oxidability of lycopene.

9. Bioavailability and nutritional value – Prof. Günter Bonn and Thomas Jakschitz (University of Innsbruck/ADSI)

  • Study of the energy content of Ozoile®.
  • In vitro evaluation of the ability to cross biological membranes to analyze bioaccessibility and bioavailability.
  • Aimed at the candidacy of Ozoile® Food as a Novel Food to the European Commission.

10. Stability of Ozoile® Food + Lycopene – Professors Pietro Campiglia and Giacomo Pepe (University of Salerno)

  • Analysis of lycopene degradation in the presence of Ozoile® and formation of oxidized species.
  • Qualitative and quantitative evaluation of stable ozonides and degraded lycopene.
  • Study of the transformation kinetics of oxidized species.
  • Analysis of acid profiles and standards of stable ozonides in mixtures.

AGREEMENTS IN PROGRESS

11. Antihyperglycemic activity – Prof. Ambrosino (Federico II University of Naples)

  • Study on animal models (mice) to evaluate the antidiabetic properties of Ozoile®, Ozoile® + Lycopene and +Oil®.
  • Preparatory to future clinical trials on patients.

12. Antidiabetic activity – Prof. Marfella (Vanvitelli University of Caserta)

  • Clinical study on patients with metabolic syndrome.
  • Objectives: to evaluate the antihyperglycemic, antihypertensive, antihypercholesterolemic and antihypertriglyceridemic effects of Ozoile® and the new supplement OZOMETRIX®.

13. Iron citrate supplement – ​​Prof. Daniele Naviglio (Federico II University of Naples)

  • Study to create a food supplement based on iron(II) citrate starting from apple juice rich in organic acids.
  • Use of the SEM patent for extraction and combination with iron filings, obtaining a highly bioavailable salt useful for correcting iron deficiencies.